Urine Organic Acid
The Metabolic Analysis Profile is a nutrition test that requires a first morning void (FMV) urine collection to measure organic acids. The report includes personalized micronutrient recommendations for vitamin and mineral cofactors as well as digestive support recommendations based on a patient’s individual biochemical metabolism.
Metabolic Analysis Profile testing is effective for patient concerns such as:
Several diseases are associated with abnormal organic acid levels such as depression, anxiety, cardiovascular disease, neurocognitive decline, diabetes, cancer, anorexia, and many others.
Test Price = 18,000 THB ($580 USD)
Urine Organic Acid - Explained
The Metabolic Analysis Profile report categorizes test results into major metabolic areas:
Metabolic Analysis Markers
Cellular Energy & Mitochondrial Metabolites
Toxin & Detoxification Markers
- Tyrosine Metabolism
Marked accumulation of organic acids in urine can signal a metabolic inhibition or block. The metabolic block may be due to a nutrient deficiency, an inherited enzyme deficit, toxic build-up, or drug effect. Enzymes that are responsible for metabolizing organic acids are vitamin and mineral dependent. With this, elevations in organic acids can reflect a functional need for these nutrients on a cellular and biochemical level, even despite normal serum levels.
Malabsorption and Dysbiosis Markers
These markers are byproducts of bacterial and fungal activity in the GI tract that can also come from the fermentation of dietary phenols and flavonoids. In the absence of dysbiosis, high levels of these metabolites can reflect a healthy intake of antioxidant-rich foods. When multiple markers are elevated, a stool test may provide further information regarding dysbiosis or other GI dysfunction.
Cellular Energy and Mitochondrial Metabolites
The cellular energy and mitochondrial metabolite markers reflect the body’s ability to process dietary macronutrients to feed the Krebs cycle (Citric Acid Cycle)
and subsequent energy production. Abnormalities throughout the Krebs cycle, as well as in fatty acid oxidation, glycolysis, and protein metabolism may reflect enzymatic dysfunction, functional nutrient insufficiencies, toxins, genetic polymorphisms, and underlying diseases. Abnormal urinary excretion of these organic acids provides a window into various clinical conditions, as well as potential therapeutic targets to correct mitochondrial dysfunction.
These organic acid compounds are down-stream metabolites of neurotransmitter synthesis and degradation. Elevations can represent altered neurotransmitter metabolism due to enzymatic nutrient cofactor needs, genetic predispositions, toxins, chronic illness, and stress.
Some organic acids are commonly used to assess the status of specific B-vitamins. By measuring organic acids that are known to rely on specific nutrients for enzymatic metabolism, clinicians can gain insight into functional vitamin needs.
Toxin and Detoxification Markers
These urinary markers can reflect exposure to environmental toxins, or up-regulation of detoxification pathways in response to exposures. Elevations lead to recommendations to identify the exposures and minimize or remove them. Clinicians may consider the use of antioxidants and nutritional support of detoxification pathways.
Tyrosine is a non-essential amino acid which can be produced in the body from phenylalanine when there is insufficient dietary intake. Abnormal downstream metabolism of tyrosine and phenylalanine produce these organic acids, which are associated with nutrient needs and some distinctive clinical conditions.